Har Gobind Khorana 1922–2011

Retrospective. Har Gobind Khorana (1922-2011).

, 1511 (2011); 334 Science Marvin Caruthers and Robert Wells 2011) − Har Gobind Khorana (1922 This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or ...

Chemical Synthesis and Purification of Oligonucleotides

Har Gobind Khorana (1922–2011): Pioneering Spirit

One of the great chemists of the 20th century died on November 9, 2011. H. Gobind Khorana, a founder of what we now call chemical biology and a pioneer at the dawn of the age of molecular biology, was 89 (see Image 1). Gobind was a creative and insightful chemist, with many landmark achievements to his credit, including the first practical synthesis of nucleotides and coenzymes in the mid-1950s...

Structure and function in rhodopsin: asymmetric reconstitution of rhodopsin in liposomes.

We report on preparation of rhodopsin proteoliposomes with the cytoplasmic domain of rhodopsin facing the exterior of the proteoliposomes. Rhodopsin purified from rod outer segments of bovine retinae by immunoaffinity chromatography in octyl glucoside was reconstituted into liposomes prepared from soybean phospholipids by detergent dialysis. The orientation of rhodopsin in the liposomes was det...

Differential dynamics in the G protein-coupled receptor rhodopsin revealed by solution NMR.

G protein-coupled receptors are cell-surface seven-helical membrane proteins that undergo conformational changes on activation. The mammalian photoreceptor, rhodopsin, is the best-studied member of this superfamily. Here, we provide the first evidence that activation in rhodopsin may involve differential dynamic properties of side-chain versus backbone atoms. High-resolution NMR studies of alph...